Th2 cells mediate the antibody response, also caused a humoral response. When we talk about Th1 cells we are talking about cell mediated immunity that releases different cytokines which don’t involve antibodies that, when in balance, become the first line of offense in treating foreign “invaders”. Th1 cells are also helpful in fighting bacteria and viruses. Th2 Dominance
Th2 cells mediate antibodies (different cytokines altogether), mainly IL-4, IL-5, IL-6, IL-10, and IL-13 and are mainly used to fight extracellular parasites, bacteria, allergens, and toxins.
Because the latter tend to cause inflammatory responses, Th2 cells are considered to be anti-inflammatory cells so, people that are are naturally predisposed to having a Th2 dominant immune system will have lower inflammation profiles.
While, as a health care practitioner, I dream of clients with balanced immune systems that release Th1 type cells when needed and Th2 cells when needed, many times, many people will have a natural predisposition towards a dominance to one or the other and, more likely, in times of dis-ease and dysfunction, depending on the imbalance, the types of immunity will be either Th1 or Th2 dominant or may even have a combination of the two swinging wildly back and forth. Th2 Dominance
We will talk about when both Th1 and Th2 immunity exists in the same patient and in the same illness in our next post.
If you are prone to seasonal allergies or food allergies that, upon exposure, create immediate and dramatic responses.
Allergy sufferers with Th2 dominance are usually tested for allergies with skin pricks and scratch tests or IgE blood levels to determine what triggers those allergies.
Common Th2 Dominance Disorders
Systemic autoimmune diseases
Allergies: food and hay fever
COPD and other airway constriction disorders
Increased stomach acidity or GERD
Excess Histamine or histamine intolerance
Chronic Fatigue Syndrome
Th2 dominance exhibit Type 1 (food and seasonal type histamine reactions), Type 2 (Grave’s Disease, Autoimmune hemolytic anemia, Rheumatic Fever), and Type 3 (lupus, Rheumatoid Arthritis) hypersensitivity. Th2 Dominance
Th2 dominance can be genetic but also can be from a parasitic infection. (Think pinworms as a child.)
Many cancer cells are killed by Th2 cells, however, chronic elevations of Th2 cells can increase incidences of breast, colorectal and pancreatic cancers.
Again, in our next installment we will be talking about what happens when both Th1 and Th2 are elevated. This week we will also be discussing the benefits of each system and finally how to balance these systems. Th2 Dominance
Wishing you health, beauty, and elegance,